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1-Pentyl-3-(1-naphthoyl)indole (also called AM-678 and JWH-018) JWH-250 is a synthetic cannabinoid receptor agonist
that has been detected
JWH-018 is a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ±
5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2 JWH-018 has an EC50 of 102 nM for human CB1 receptors, and 133 nM
for human CB2 receptors. JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3-3 mg/kg, suggesting
potent cannabinoid-like activity.
JWH-250 is a synthetic cannabinoid receptor agonist that has been detected? The drug is a phenylacetylindole and it
works as an agonist at CB1 and CB2 receptors. It has an affinity of ~11 nM at CB1 and ~33 nM at CB2. Those samples
contained 77-165 mg per product.
Because of the way it’s been sold, it’s likely people have encountered JWH-250 without realizing it. JWH-250 = 1-pentyl-
3-(2-methoxyphenylacetyl)indole. Unlike many of the older JWH series compounds, this compound does not have a
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